Matthias Keller

Formation of Intracardiac Electrograms under Physiological and Pathological Conditions

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Formation of Intracardiac Electrograms under Physiological and Pathological Conditions
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This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.